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Why we honor and insist on hand sew our leather product ?
Leather sewing machines commonly use the "lock stitch" , If just one loop of a lock stitch is broken, the other side will automatically be loosened, often this process of unraveling will continue until the entire product is ruined.
Hand sewing (saddle stitch) will not unravel if one loop is broken.
Though slower, hand sewing is superior to machine sewing. It is the best way to sew leather together,the hand-sew leather product will be more durable and stand the test of time !!
DISTRESSED LEATHER TRAVEL DOCUMENT WALLET / HOLDER
Stylish document travel holder for boarding passes ( train tickets), passports, money ,card and other useful things that should always be on hand when traveling. It is perfect for your travelled..Me and our team travel to Norway and Iceland at July ,2015 and update the design of this wallet according to our use experience ^-^
On the left
- boarding pass/ticket / Receipt holder
- cash / phone compartment (max size up to Iphone 6 plus)
On the right
- passport compartment
- three slot for credit card
***** Description and Features *****
- Materials: 100% Luxury Distressed Genuine Leather
- Hand cut,Hand sew with thick waxed thread
- Unique design for passport holder
- Size : 21cm * 10cm ( 8" x 4" )
***** shipping *****
We offer Standard shipping service ( USPS First Class International Mail) and Express shipping service ( TNT Express ),please feel free to write us ,thank you .
* Standard shipping service: 9~12 business days to delivery
* TNT Express: 3~5 business days to delivery
* A contact phone number is required by express ,please write us by message ,thank you
Molecular pathway of estrogen receptor (ER) action. Typically, estrogen binds to the ligand-binding domain of receptors in the nucleus, which causes a conformational change. Estrogen-responsive elements (ERE) mediate genomic effects. RE, response element; TF, transcription factor; GF, growth factor; GF-R, growth factor receptor; CoA, co-activator; CoR, co-repressor; MAPK, mictogen-activated protein kinase; PI3K, phophoinositide 3-kinase; Src, proto-oncogene tyrosine-protein kinase; AP-1, activating protein-1; Sp-1, stimulating protein-1. Adapted from Nie et al.16
Measurement parameters utilized to determine the esophageal motor function. (A) Esophagogastric junction (EGJ). (B) Esophageal body. EGJ-CI, esophagogastric junction-contractile integral; IRP, integrated relaxation pressure; LES, lower esophageal sphincter.
High-resolution manometry test swallows and maneuvers. (A) Supine 5 mL liquid; (B) upright 5 mL liquid; (C) viscous (apple sauce); (D) solid (graham cracker); (E) multiple rapid swallow; and (F) rapid drink challenge. Integrated relaxation pressure (IRP) and distal contractile integral (DCI) were 11 mmHg and 1760 mmHg·cm·sec (A), 8 mmHg and 1950 mmHg·cm·sec (B), 7 mmHg and 1600 mmHg·cm·sec (C), 10 mmHg and 1400 mmHg·cm·sec (D), 4 mmHg and 4600 mmHg·cm·sec (E), and 3 mmHg and 0 mmHg·cm·sec (F), respectively. Figure used with permission from the Esophageal Center at Northwestern.
Our diagnostic algorithm of defecation disorders using a colonic transit study. DD, defecation disorders; DRE, digital rectal examination; NTC, normal transit constipation; STC, slow transit constipation; RS, rectosigmoid colon.
Statistical maps showing voxel-mirrored homotopic connectivity (VMHC) differences between irritable bowel syndrome (IBS) and healthy controls (HCs;